Enabling membrane protein structure and dynamics with X-ray free electron lasers
نویسندگان
چکیده
منابع مشابه
X-ray free-electron lasers
In a free-electron laser (FEL) the lasing medium is a high-energy beam of electrons flying with relativistic speed through a periodic magnetic field. The interaction between the synchrotron radiation that is produced and the electrons in the beam induces a periodic bunching of the electrons, greatly increasing the intensity of radiation produced at a particular wavelength. Depending only on a p...
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The history of the living world can be summarised as an elaboration of ever more perfect eyes within a Cosmos in which there is always something new to be seen (Teilhard du Chardin, 1955). Today, the bottleneck in the atomic resolution imaging of biological systems is a fundamental need for crystals. This limits the scope of detailed structural analysis to macromolecules and macromolecular asse...
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The planned construction of an X-ray free-electron laser (XFEL) will provide new opportunities for research in various areas of physics, chemistry and biology. The proposed design of the XFELs at DESY (Deutsches Elektronen-Synchrotron) and SLAC (Stanford Linear Accelerator Center) is built on the concept of a fourth-generation synchrotron source and will provide an intense pulse (I(0) approxima...
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The ultrafast pulses from X-ray free-electron lasers will enable imaging of non-periodic objects at near-atomic resolution [1]. These objects could include single molecules, protein complexes, or virus particles. The specimen would be completely destroyed by the pulse in a Coulomb explosion, but that destruction will only happen after the pulse. The scattering from the sample will give structur...
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ژورنال
عنوان ژورنال: Current Opinion in Structural Biology
سال: 2014
ISSN: 0959-440X
DOI: 10.1016/j.sbi.2014.05.002